The Signature of All Things

botanist in the Americas, but also blisteringly rich—and if he wanted a pineapple in January, by God he could have a pineapple in January. Cherries in March, as well.
    He then retired to his study and opened up his ledger, where, as he did every night, he recorded all manner of estate transactions, both official and intimate. He began: “A new nobbel and entresting pasennger has joyned us,” and continued with the details, the timing, and the expenses of Alma Whittaker’s birth. His penmanship was shamefully crabbed. Each sentence was a crowded village of capital letters and small letters, living side by side in tight misery, crawling up on one another as though trying to escape the page. His spelling was several degrees beyond arbitrary, and his punctuation brought reason to sigh with unhappiness.
    But Henry wrote up his account, nonetheless. It was important for him to keep track of things. While he knew that these pages would look appalling to any educated man, he also knew that nobody would ever see his writing—except his wife. When Beatrix recovered her strength, she would transcribe his notes into her own ledgers, as she always did, and her elegantly penned translation of Henry’s scrawls would become the official household record. The partner of his days, was Beatrix—and a good value, at that. She would do this task for him, and a hundred other tasks besides.
    God willing, she would be back at it shortly.
    Paperwork was already piling up.

Cinchona calisaya, var. ledgeriana

PART ONE
    The Tree of Fevers

Chapter One
    F or the first five years of her life, Alma Whittaker was indeed a mere passenger in the world—as we all are passengers in such early youth—and so her story was not yet noble, nor was it particularly interesting, beyond the fact that this homely toddler passed her days without illness or incident, surrounded by a degree of wealth nearly unknown in the America of that time, even within elegant Philadelphia. How her father came to be in possession of such great wealth is a story worth telling here, while we wait for the girl to grow up and catch our interest again. For it was no more common in 1800 than it has ever been for a poor-born and nearly illiterate man to become the richest inhabitant of his city, and so the means by which Henry Whittaker prospered are indeed interesting—although perhaps not noble, as he himself would have been the first to confess.
    Henry Whittaker was born in 1760 in the village of Richmond, just up the Thames from London. He was the youngest son of poor parents who had a few too many children already. He was raised in two small rooms with a floor of beaten earth, with an almost adequate roof, with a meal on the hearth nearly every day, with a mother who did not drink and a father who did not beat his family—by comparison to many families of the day, in other words, a nearly genteel existence. His mother even had a private spot of dirt behind the house in which to grow larkspurs and lupines, decoratively, like a lady. But Henry was not fooled by larkspurs and lupines. Hegrew up sleeping one wall away from the pigs, and there was not a moment in his life when poverty did not humiliate him.
    Perhaps Henry would have taken less offense at his destiny had he never seen wealth around him against which to compare his own poor circumstances—but the boy grew up witnessing not only wealth, but royalty. There was a palace at Richmond, and there were pleasure gardens there, too, called Kew, cultivated with expertise by Princess Augusta, who had brought with her from Germany a retinue of gardeners eager to make a false and regal landscape out of real and humble English meadows. Her son, the future King George III, spent his childhood summers there. When he became king, George sought to turn Kew into a botanical garden worthy of any Continental rival. The English, on their cold, wet, isolated island, were far behind the rest of Europe on botanizing, and George III was eager to catch up.
    Henry’s father was an orchardman at Kew—a humble man, respected by his masters, as much as anyone could respect a humble orchardman. Mr. Whittaker had a gift for fruiting trees, and a reverence for them. (“They pay the land for its trouble,” he would say, “unlike all the others.”) He had once saved the king’s favorite apple tree by whip-grafting a scion of the ailing specimen onto sturdier rootstock and claying it secure. The tree had fruited off the new graft that